Clinical Evidence

The technology behind AcceleDent® is predicated on the application of pulsatile forces to move teeth faster by accelerating the bone remodeling process. Dr. Jeremy Mao conducted in vivo animal studies in the early 2000’s at the University of Illinois-Chicago, and these initial studies served as the foundation for the scientific understanding and technology development of AcceleDent. Over time, subsequent studies have been published on accelerated bone remodeling with pulsatile forces in a variety of animal models, and they have shed light on the biological response at the cellular level.

In addition to the multiple in vivo scientific studies, AcceleDent has been clinically proven to accelerate tooth movement by up to 50% in a U.S. randomized controlled trial. Since 2009, published clinical research and case reports continue to build in support of AcceleDent’s clinical effectiveness and safety.

View a full list of Comprehensive Peer-Reviewed Clinical Evidence regarding AcceleDent. It categorizes, summarizes and links to the 14 peer-reviewed studies, including 3 RCTs, supporting AcceleDent. 

Acceleration by Vibration Article in Orthodontics Products

Clinical Evaluation of a Novel Cyclical Force Generating Device in Orthodontics

Efficacy Pilot Study – Published Case Reports

A Radiographic Analysis of Tooth Morphology Following the Use of a Novel Cyclical Force Device in Orthodontics

Advances in Orthodontic Treatment – PennWell

Clinical Studies

Accelerating aligner treatment using low-frequency vibration: a single-centre, randomized controlled clinical trial
Lombardo, L. et al., 2018. European Journal of Orthodontics, pp. 1-10.

Cyclic Loading (Vibration) Accelerates Tooth Movement in Orthodontic Patients: A Double-Blind, Randomized Controlled Trial
Pavlin, D. et al., Anthony, R., Raj, V., and Gakunga, P.T., 2015. Seminars in Orthodontics, 21(3), pp. 187-194.

Pain Control in Orthodontics Using a Micropulse Vibration Device: A Randomized Clinical Trial
Lobre, W. et al., Callegari, B.J., Gardner, G., Marsh, C.M., Bush, A.C., and Dunn, W.J., 2015. The Angle Orthodontist, in press.

Clinical Experience with the Use of Pulsatile Forces to Accelerate Treatment
Orton-Gibbs, S., and Kim, N.Y., 2015. Journal of clinical orthodontics: JCO, 49(9), pp. 557-573.

A Radiographic Analysis of Tooth Morphology Following the Use of a Novel Cyclical Force Device in Orthodontics
Kau, C.H., 2011. Head & Face Medicine, 7(14), pp. 1-5.

The Clinical Evaluation of a Novel Cyclical Force Generating Device in Orthodontics
Kau, C.H., Nguyen, J.T., and English, J.D., 2010. Orthodontic Practice US, 1(1), pp.10-15.

Computational and Clinical Investigation on the Role of Mechanical Vibration on Orthodontic Tooth Movement
Liao, Z., Elekdag-Turk, S., Turk, T., Grove, J., Dalci, O., Chen, J., Zheng, K., Darendeliler, M., Swain, M., Li, Q., 2017. Journal of Biomechanics, 60, pp. 57-64.

Case Reports

Increasing Orthodontic and Orthognathic Surgery Treatment Efficiency with a Modified Surgery-First Approach
Uribe et al. Am J Orthod Dentofacial Orthop 2015;148:838-48.

A Novel Device in Orthodontics
Kau C.H., 2009. Aesthetic Dentistry Today, 3(6), pp. 42-43.

Orthodontic Movement Using Pulsating Force-Induced Piezoelectricity
Shapiro, E., Roeber, F.W., and Klempner, L.S, 1979. American Journal of Orthodontics, 76(1), pp. 59-66.

Acceleration Extraction Treatment with Invisalign
Ojima, K., Schupp, W., et al., 2014. Journal of clinical orthodontics, pp. 487-499.

In Vivo Studies

Suture Growth Modulated by the Oscillatory Component of Micromechanical Strain
Kopher, R.A., and Mao, J.J., 2003. Journal of Bone and Mineral Research, 18(3), pp. 521-528.

Geometry and Cell Density of Rat Craniofacial Sutures During Early Postnatal Development and Upon In Vivo Cyclic Loading
Vij, K., and Mao, J.J., 2006. Bone,38(5), pp. 722-730.

Responses of Intramembranous Bone and Sutures Upon In Vivo Cyclic Tensile and Compressive Loading
Peptan, A.I., Lopez, A., Kopher, R.A., and Mao, J.J., 2008. Bone, 42(2), pp. 432-438.

Periodontal Tissue Activation by Vibration: Intermittent Stimulation by Resonance Vibration Accelerates Experimental Tooth Movement in Rats
Nishimura, M., Chiba, M., Ohashi, T., Sato, M., Shimizu, Y., Igarashi, K., and Mitani, H., 2008. American Journal of Orthodontics and Dentofacial Orthopedics, 133(4), pp. 572-583.

Acceleration of Orthodontic Tooth Movement by Mechanical Vibration
Liu, D., 2010. Presented in AADR Annual Meeting. Washington, DC.

Effects of Pulsed Electromagnetic Field Vibration on Tooth Movement Induced by Magnetic and Mechanical Forces: A Preliminary Study
Darendeliler, M.A., Zea, A., Shen, G., and Zoellner, H., 2007. Australian Dental Journal, 52(4), pp. 282-287.

Expression and Mechanical Modulation of Matrix Metalloproteinase-1 and-2 Genes in Facial and Cranial Sutures
Al-Mubarak, R., Da Silveira, A., and Mao, J.J., 2005. Cell and tissue research, 321(3), pp. 465-471.

Expression of Matrix Metalloproteinase Genes in the Rat Intramembranous Bone During Postnatal Growth and Upon Mechanical Stresses
Collins, J.M., Ramamoorthy, K., Da Silveira, A., Patston, P., and Mao, J.J., 2005. Journal of Biomechanics,38(3), pp. 485-492.

In Vitro Studies

The Effects of Gentle Micropulse Vibration on Two Types of Murine Osteoblasts
García-López, S., Villanueva, R., and Meikle, M.C., 2015. Paper presented at the 2015 Annual Session May 15-19, AAO, San Francisco, CA.

Effect of Low-Magnitude, High-Frequency Vibration on Osteocytes in the Regulation of Osteoclasts
Lau, E., Al-Dujaili, S., Guenther, A., Liu, D., Wang, L., and You, L., 2010. Bone, 46(6), pp. 1508-1515.