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Scientific Evidence

The technology behind AcceleDent® is predicated on the application of cyclic forces to move teeth faster by accelerating the bone remodeling process.  Dr. Jeremy Mao conducted the first animal studies in the early 2000’s, which initially served as the foundation for scientific research in this field.

Over time, subsequent studies have been published on accelerated bone remodeling in a variety of animal models, and they have shed light on the biological response at the cellular level.  AcceleDent® is the result of technology development and scientific advancement from the outcome of these early scientific studies.

Kopher, Ross A., and Jeremy J. Mao. “Suture growth modulated by the oscillatory component of micromechanical strain.” Journal of Bone and Mineral Research 18.3 (2003): 521-28.

Vij, Kapil, and Jeremy J. Mao. “Geometry and cell density of rat craniofacial sutures during early postnatal development and upon in vivo cyclic loading.” Bone 38.5 (2006): 722-730.

Peptan, Alexandra I., Aurora Lopez, Ross A. Kopher, and Jeremy J. Mao. “Responses of intramembranous bone and sutures upon in vivo cyclic tensile and compressive loading.” Bone 42.2 (2008): 432-38.

Nishimura, Makoto, Mirei Chiba, Toshiro Ohashi, Masaaki Sato, Yoshiyuki Shimizu, Kaoru Igarashi, and Hideo Mitani. “Periodontal tissue activation by vibration: Intermittent stimulation by resonance vibration accelerates experimental tooth movement in rats.” American Journal of Orthodontics and Dentofacial Orthopedics 133.4 (2008): 572-83.

Liu, D. “Acceleration of Orthodontic Tooth Movement by Mechanical Vibration.” 2010 AADR Annual Meeting. Washington, DC.

Liu, D. “Histomorphometric Study of Orthodontic Tooth Movement under Mechanical Vibration.” 2011 AADR General Session. San Diego, CA.